Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) is an advanced form of ICSI (Intracytoplasmic Sperm Injection) that offers a more detailed analysis of sperm morphology to improve the chances of fertilization, particularly in cases where male infertility is the primary concern. IMSI is particularly beneficial for couples experiencing severe male infertility, including issues like poor sperm quality, low sperm count, or high sperm DNA fragmentation.

At Mediyaz ART Bank, we offer cutting-edge IMSI treatments using the latest technology to enhance your chances of conception. This treatment is a significant breakthrough in assisted reproduction, and we are committed to providing you with the highest standard of care throughout your fertility journey.

What is IMSI Treatment?

IMSI (Intracytoplasmic Morphologically Selected Sperm Injection) is a highly advanced fertility treatment that involves selecting the healthiest sperm for fertilization with a more detailed examination under a microscope. In IMSI, sperm is analyzed under a very high-powered microscope (magnification of up to 6000 times), allowing the embryologist to select sperm with the best morphology, i.e., sperm that is less likely to have genetic defects.

This technique is an enhancement over the traditional ICSI, where sperm is injected directly into the egg. IMSI helps in selecting the sperm with the best possible shape and structure, which can improve the chances of success in cases of male infertility, especially when there is sperm DNA fragmentation or abnormal sperm morphology.

Eligibility for IMSI Treatment in India

IMSI treatment is typically recommended in situations where male infertility is severe or where ICSI has previously resulted in poor outcomes. Below are some common situations where IMSI might be recommended:

1. Male Infertility Issues

IMSI is particularly helpful in cases where the male partner has:

• Severe sperm abnormalities (low sperm count, poor sperm motility, abnormal sperm morphology).
• Sperm DNA fragmentation: This is when the genetic material inside the sperm is damaged, which can significantly reduce fertility and increase the risk of miscarriage.
• Previous ICSI Failures: If previous ICSI treatments have failed due to poor fertilization, IMSI may be considered as a better alternative.

2. High Sperm DNA Fragmentation

IMSI is highly beneficial in cases where sperm DNA fragmentation is a concern, as it allows for the selection of sperm with the least genetic damage, improving the chances of successful fertilization and a healthy pregnancy.

3. Unexplained Male Infertility

In some cases where the cause of male infertility is unknown, IMSI is recommended as it provides a more thorough sperm selection process, increasing the chances of fertilization.

4. Previous IVF or ICSI Failures

IMSI is often suggested for couples who have undergone multiple IVF/ICSI cycles without success, particularly if sperm quality was suspected to be a contributing factor.

5. Older Female Partners

For older women, IMSI can be beneficial, as it helps to ensure that the sperm used for fertilization is of the highest possible quality, which is crucial when egg quality is a concern.

The IMSI Process at Mediyaz ART Bank

The IMSI treatment process at Mediyaz ART Bank is similar to the standard ICSI procedure but with the added step of enhanced sperm selection using high magnification. Below is an overview of the typical IMSI treatment process:

1. Initial Consultation and Assessment

Your treatment begins with a comprehensive consultation with one of our fertility specialists. This includes:

• Reviewing your medical history and any previous infertility treatments.
• Conducting diagnostic tests for both partners, including semen analysis for the male partner and ultrasounds for the female partner.
• Discussing the treatment plan, including whether IMSI is the best option for your particular case.

2. Ovarian Stimulation for the Female Partner

The female partner undergoes ovarian stimulation using hormonal injections that encourage the ovaries to produce multiple eggs. This is closely monitored with blood tests and ultrasound scans to track the growth of the follicles.

3. Sperm Collection and Preparation

On the day of the egg retrieval, the male partner provides a sperm sample. If sperm is not present in the ejaculate, sperm may be retrieved directly from the testes or epididymis through surgical sperm retrieval procedures like TESE or PESA.

Once the sperm sample is obtained, it is prepared in the lab by the embryologist. This includes washing and concentrating the sperm, followed by IMSI analysis. Using a high-powered microscope (magnification of up to 6000x), the embryologist selects the best quality sperm based on its morphology.

4. Sperm Injection (IMSI)

Once the best sperm is selected, the IMSI procedure involves injecting the sperm directly into the egg, similar to the ICSI procedure. This helps bypass male fertility issues like low sperm count or poor motility and maximizes the chances of successful fertilization.

5. Embryo Culture

After fertilization, the embryos are cultured for 3 to 5 days in the laboratory, and their growth is closely monitored. The embryos are checked for their quality, and the best embryos are selected for transfer.

6. Embryo Transfer

The selected embryos are transferred into the woman’s uterus using a simple, non-invasive procedure. This is done under ultrasound guidance to ensure the correct placement of the embryos.

7. Pregnancy Test and Follow-up

About 10 to 14 days after the embryo transfer, a blood test is performed to check for pregnancy. If the test is positive, further ultrasounds will be scheduled to confirm the pregnancy and monitor its progress.

8. Post-Treatment Care

Our team will provide ongoing support to monitor the early stages of pregnancy, offering both medical and emotional support to ensure the well-being of both the mother and the developing baby.

Cost of IMSI Treatment in India

The cost of IMSI treatment is higher than traditional ICSI due to the advanced technology used for sperm selection. At Mediyaz ART Bank, the approximate cost for an IMSI cycle ranges between ₹2,50,000 to ₹3,50,000 per cycle. The cost typically includes:

• Ovarian stimulation medications
• Egg retrieval and sperm analysis
• IMSI sperm selection and injection
• Embryo culture and transfer

Additional costs may arise for:

• Sperm retrieval procedures like TESE or PESA (₹40,000 to ₹60,000).
• Genetic screening (PGD/PGS): ₹50,000 to ₹1,00,000.
• Sperm donor (if applicable): ₹50,000 to ₹1,00,000.

Success Rate of IMSI Treatment at Mediyaz ART Bank

The success rate of IMSI treatment is influenced by multiple factors, including the age and health of the female partner, sperm quality, and the overall fertility profile of the couple. At Mediyaz ART Bank, we use the latest technology and techniques to maximize the chances of success.

• For women under 35, the success rate for IMSI can be 50-60% per cycle, depending on sperm quality and the cause of infertility.
• For women aged 35-40, the success rate is typically 40-50% per cycle.
• For women over 40, success rates tend to decrease, but IMSI can still be beneficial in selecting high-quality sperm, which improves the chances of pregnancy.

Success rates can vary, and our fertility specialists will provide you with a more personalized success estimate based on your unique fertility situation.

Why Choose Mediyaz ART Bank for IMSI Treatment?

At Mediyaz ART Bank, we offer:

• Advanced Technology: We use state-of-the-art equipment, including high-powered microscopes, to perform IMSI, ensuring the best sperm is selected for fertilization.
• Expert Care: Our team of fertility specialists, embryologists, and support staff work closely with you to ensure the best possible outcome.
• Personalized Treatment Plans: We understand that each couple’s fertility journey is unique, and we provide customized treatment plans based on your specific needs.
• High Success Rates: Our expertise in IMSI and other assisted reproductive technologies ensures that we deliver the highest success rates possible.
• Comprehensive Support: From initial consultation to post-treatment care, we are committed to supporting you throughout your fertility journey.

Get Started with IMSI Treatment at Mediyaz ART Bank

If you are struggling with male infertility or have faced difficulties with previous IVF/ICSI treatments, IMSI might be the solution you need. Mediyaz ART Bank is here to help you navigate every step of the process, from consultation to successful pregnancy.